Use of Polysaccharide Hydrogels in Drug Delivery and Tissue Engineering

Present review article aims to explain use of injectable hydrogels and microspheres derived from natural polysaccharides as drug delivery systems and cell scaffolds. Polysaccharides isolated from natural sources are proved much better than synthetic polymers for making single and composite hydrogels. This paper emphasizes recent developments occurred in use of amphiphilic polysaccharides for biomedical applications. It also explains use of various injectable polysaccharide structure-based hydrogels such as carboxymethyl chitin, hyaluronic acid, PTX-loaded modified hydrogels, Thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel, Gellan Gum ,ChitinCaSO4-nano-fibrin based injectable gel system, nanocomposite hydrogels, chondroitin Sulfate, photo-crosslinked gelatin methacrylate (GelMA) and thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogels and its functions in engineering cartilage tissue and injectable chemistries. More specifically, this paper high light use of combining analogous matrices with cells/stem cells and biomolecules and multi component approaches for making mimetic constructs. There is a need to develop more advanced designs of polysaccharide-based injectable hydrogels to widen the horizons of clinical drug delivery applications in biomedical engineering and several fields related to pharmaceutics.